Norm Smith medallist Jason Johannisen is set for a stint on the sidelines after going down with an ankle injury at training on Friday.
Western Bulldogs speedster Johannisen is set to be assessed in the coming days, having left the track early after being hurt in a tackle.
The absence of Johannisen looms as a major blow for the Dogs after they missed the finals in consecutive seasons since winning the 2016 premiership, a game in which Johannisen was voted best afield.
Meanwhile Carlton announced late on Friday that they had signed midfielder Michael Gibbons and wingman Matthew Cottrell as rookies.
Dual Liston Trophy winner Gibbons and teenager Cottrell had both been training with the Blues in the hope of getting a chance in accordance with new supplemental selection period rules.